A DISTAL INTERGENIC REGION CONTROLS PANCREATIC ENDOCRINE DIFFERENTIATION BY ACTING AS A TRANSCRIPTIONAL ENHANCER AND AS A POLYCOMB RESPONSE ELEMENT.

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.

Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms.Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences.Gene repression often depends on the recruitment of Polycomb group (PcG) proteins, although the sequences

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Identification Markers Responsible for Differentially Processed Polygonatum cyrtonema Hua by Ultra-Performance Liquid Chromatography with Quadruple-Time-of-Flight Mass Spectrometry

The dietrich scissors rhizome of Polygonatum cyrtonema Hua has been used as a traditional Chinese medicine for over 2000 years.The fresh Chinese herb possesses micro toxicity and is thus traditionally alternately steamed and basked nine times to alleviate the toxicity and enhance the pharmaceutical efficacy.Different processing cycles usually resul

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